Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695-696
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Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695–696
In the March issue of Diabetes, there is a very interesting article by Jurczak et al. (1) about glucose homeostasis and b-cell function in mice with a deletion in SGLT-2. There is also an accompanying editorial by Ferrannini (2) that is appropriately laudatory to the article but there are some extraordinary comments including, “Collectively, these findings prove that reduced SGLT-2 activity—whe...
متن کاملResponse to Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695–696
The comment that Dr. Stanton found extraordinary reads as follows: “Collectively, these findings prove that reduced SGLT-2 activity—whether genetically or experimentally induced—is efficacious and relatively safe..” (1). This sentence referred to the animal studies described in the preceding paragraph, as becomes even more apparent in the following sentence that reads: “The development of SGLT-...
متن کاملComment on Ferrannini et al. Diabetes Care 2016;39:1108-1114. Comment on Mudaliar et al. Diabetes Care 2016;39:1115-1122.
In their recent articles, Ferrannini et al. (1) and Mudaliar et al. (2) suggest that increased ketonemia, improving heart function, might explain the positive results of the BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) study. This suggestion perfectly fits with our recently published hypothesis that glucagon could be the key...
متن کاملLearning From Glycosuria
Plasma glucose is filtered freely through the glomerular barrier. In a 70-kg adult with a glomerular filtration rate of 120 mL $ min per 1.73 m and an average, around-the-clock plasma glucose concentration of 120 mg/dL (6.7 mmol/L), ;200 g of glucose are transferred daily from the bloodstream into the preurine. If nothing else happened, the whole-body mass of free glucose (some 20 g in a distri...
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Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due tomutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I antiarrhythmic drug, inhibits Na and RyR2 channels and prevents CPVT. The purpose of this study is to identify inhibitory mechanisms of flecainide on RyR2. RyR2 were isolated from sheep heart, incorpor...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2011
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db11-0483